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Dr. Marusak interviewed about endocannabinoids and exercise
Dr. Marusak interviewed about endocannabinoids and exercise
2021
THINK LAB
Dept. of Psychiatry and Behavioral Neurosciences
Wayne State University School of Medicine
About
The "THINK" in THINK lab stands for Trauma History Investigation of Neurodevelopment in Kids. We study the impact of stress and trauma during childhood on brain development in children and adolescents, as well as, neurodevelopmental mechanisms leading to anxiety and other "fear-based" disorders, such as posttraumatic stress disorder (PTSD). These disorders are extremely common and affect about one in three people at some point during their lifetime. Fear-based disorders also begin during childhood and adolescence, so our research takes a developmental approach.
Research Themes
- The impact of environmental adversity on brain and behavioral development in children and adolescents. This includes childhood trauma —such as interpersonal forms of trauma (e.g., violence, peer victimization) and medical-related trauma (e.g., cancer diagnosis, treatments), and also environmental toxicants (e.g., particulate matter air pollution, lead).
- The role of the endocannabinoid system in modulating frontolimbic brain development and risk of fear-based disorders.
- Behavioral (e.g. exercise, meditation) or pharmacological interventions (e.g., cannabidiol, CBD) that target the endocannabinoid system for the treatment and/or prevention of fear-based disorders in youth.
- The impact of prenatal cannabis exposure and adolescent cannabis use on neurodevelopmental and mental health outcomes.
- Effects of cannabis and cannabinoids on the brain and mental health outcomes.
Techniques
To study brain development in children and adolescents, our research uses several neuroscientific techniques, including functional magnetic resonance imaging (fMRI), structural MRI, electroencephalography (EEG), blood and saliva biomarkers, genetic variants, skin conductance responses (SCRs), and behavior.
Ongoing Research Studies
Volunteer for paid research opportunities
Participate in paid research studies!
Click below to complete a form to be contacted about research opportunities!
Wayne State ABCD study
Adolescent Brain Cannabinoid Development (ABCD) Study: Parents of 10-17 yr olds living in Detroit or the surrounding areas: Take a brief online survey and have your child complete a brief survey and earn a $20 e-gift card for your participation!
Help Wayne State researchers understand the things that children & teens experience. Your child may also be eligible for a larger study that compensates up to $380. Watch this 2-minute video to learn more about the study. Contact us to get started!
CBD Study
This study is to examine the effects of cannabidiol (CBD) on anxiety and behavioral problems among children with epilepsy. In partnership with Dr. Aimee Luat, MD (Children's Hospital of Michigan).
E = MBH
This study is to learn about the beneficial effects of exercise and endocannabinoids on mental and brain health in 9-17-year-old children. In partnership with Dr. Jeanne Barcelona, PhD (WSU Center for Community Health).
Warrior C.A.R.E.
The overall goal of this research program is to understand how cannabis affects mental health in United States armed forces veterans.
PATH Study
The Peer Adjustment and Teen Health (PATH) study is being conducted in partnership with Dr. Hannah Schacter's lab (WSU Department of Psychology). This study examines the impact of social experiences on health of teens, ages 10-17 years.
BRAINS Study: Coming Soon
Research opportunity for 14-17 yr-olds and one parent/guardian: Help Wayne State researchers learn about the effects of exercise on brain health in youth!
Canna Mama Study: Coming Soon
Survey for pregnant people about their perceptions and use of cannabidiol (CBD) and other substances during pregnancy.
Recent Publications
For a list of the THINK lab's published research, click here
Smaller hippocampal volume is associated with reduced posttraumatic stress symptoms in children with cancer and survivors following a brief novel martial arts-based intervention
Archives of Clinical Neuropsychology (2023)
Strong mind, strong body: The promise of mind-body interventions to address growing mental health needs among youth
Mental Health Sci (2023)
Getting a good night's sleep: Associations between sleep duration and parent-reported sleep quality on default mode network connectivity in youth
Journal of Adolescent Health (2023)
Air pollution, depressive and anxiety disorders, and brain effects: A systematic review
Neurotoxicology (2022)
Impact of prenatal cannabis exposure on functional connectivity of the salience network in children
J Neurosci Res (2022)
Impact of childhood trauma exposure, genetic variation in endocannabinoid signaling, and anxiety on frontolimbic pathways in children
Cannabis and Cannabinoid Research (2022)
Meditation reduces brain activity in the default mode network in children with active cancer and survivors
Pediatric Blood & Cancer (2022)
LAB MEMBERS
Meet the minds of the THINK Lab
Principal Investigator
(she/her/hers)Dr. Marusak is a tenure-track Assistant Professor in the Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine. She also has a secondary faculty appointment Merrill Palmer Skillman Institute for Child and Family Development and the Department of Pharmacology, is a Scientific Member of the Karmanos Cancer Institute and the CURES Center, and a Science Advisor for the nonprofit organization Kids Kicking Cancer.
Postdoctoral Research Fellow
(she/her/hers)Dr. Zundel earned her Bachelor of Science in Psychology from Wayne State University, then went on to complete a PhD in Behavioral Neuroscience at Boston University School of Medicine. Her PhD work focused on the effects of neurotoxicant exposures on aging within the Gulf War veteran population, using neuropsychological assessment and structural brain imaging techniques. Dr. Zundel’s research interests include the impact of environmental stressors, particularly urban air pollution, on neurodevelopment and mental health in children and adolescents.
Research Coordinator & Lab Manager
(she/her/hers)
Leah graduated from the University of Michigan in 2022, earning a B.A. with a double major in Psychology and History. She is interested in examining how adverse childhood experiences impact brain and behavioral development. Leah plans to apply to clinical psychology PhD programs for a Fall 2024 start. Outside of the lab, Leah enjoys playing with her kitten, powerlifting, and watching Marvel movies.
Neuroscience Ph.D. Student
(she/her/hers)Sam attended Albion College where she graduated with a Bachelor's degree in Psychology, concentrating her studies in neuroscience. She is currently a second-year PhD student in the Translational Neuroscience Program at Wayne State University. Her broad research interests include investigating the neurodevelopmental mechanisms of anxiety- and stress-based disorders. Outside of the lab, Sam enjoys painting, photography, hiking, and other outdoor activities.
Research Assistant & Social Media Director
(she/her/hers)Aman earned her B.S. in Psychology in 2019 from Wayne State University. Her recent work at the lab has focused on the impact of perceived discrimination regarding sexual orientation on mental health and neurodevelopmental (e.g., brain structure) outcomes. Additionally, Aman has been interested in bridging the communication of research to the lay audience with her creative work in film. Aman will be applying to doctoral programs for fall of 2024.
Research Technologist
(she/her/hers)Reem is a Computer Science graduate from Wayne State University as of May 2022. She is currently pursuing a Master's Degree in Data Science and Business Analytics. Reem's interests lie in the field of neuroimaging.
Research Assistant
(she/her/hers)
Carmen is currently a third year undergraduate student at Wayne State University. She is pursuing a Bachelor’s Degree with a major in Psychology and Criminal Justice. She plans to pursue a PhD in Clinical Psychology and ultimately study the mental health of prisoners.
MacKenna recently graduated from Hope College in May 2023 with a B.A. in Psychology. Her research interests include post-traumatic therapeutic interventions, resilience, and heart rate variability. MacKenna plans to pursue her doctoral degree in clinical psychology to work clinically and in academic settings. In her free time, she enjoys reading, coffee, and paddle boarding.
Research Volunteer
(he/him/his)Aneesh is a medical student at Wayne State University School of Medicine. He completed his bachelor's degree in Biological Sciences at Wayne State University. He is interested in pursuing a career in Child & Adolescent Psychiatry and/or Neuropsychiatry.
Research Volunteer
(she/her/hers)Shelley is currently an undergraduate student at Wayne State University majoring in Public Health and minoring in Neuroscience. She is currently studying for the MCAT and her plans are to apply to medical school and specialize in Pediatric Oncology. Shelley has been a research assistant in Dr. Marusak's lab for over 4 years and has worked on several projects and co-authored 2 publications. In her free time, she enjoys spending time with her son and cat.
Research Volunteer
Jennifer is an alumnus of Central Michigan University with her bachelor's degree in Psychology. She is currently a second-year graduate student in the Basic Medical Sciences program at Wayne State University. Jennifer is interested in better understanding the biological and environmental factors that puts children at risk for development of psychiatric disorders and utilizing neuroimaging techniques to evaluate structural and functional brain changes associated with psychiatric disorders.
Student Research Assistant, Richard Barber Fellow
(she/her/hers)
Mariya is currently an undergraduate student at Wayne State University majoring in neuroscience and minoring in psychology. She loves to learn about various fields of neuroscience, specifically developmental, cognitive and behavioral. Mariya is also interested in health psychology which ties in with her current research about the effects of exercise, meditation, and stretching on anxiety in youth.
Research Volunteer, Richard Barber Fellow
(she/her/hers)Sarah is currently a senior undergrad student at WSU and in her last semester of her bachelor's degree in Exercise and Sports Science. Additionally, she will begin grad school in the fall to pursue her master’s degree. She also has an associate degree in business and plans on earning 500-hour yoga cert next year. She loves learning and working out. When she is not hitting the books, she is in the gym, doing yoga, or doing research on health and fitness. She also really loves being outdoors. Her favorite pastime is fishing, but she enjoys anything that involves camping, hiking, or being in or by water.
Research Volunteer
(he/him/his)Jovan is currently a Medical Student at the Wayne State University School of Medicine with an interest in intervention development and translational research. He has a background in mental health research and cognitive development, and is hoping to build and add to this experience while a part of the THINK lab. He hopes to take this experience and leverage it as a clinician in the future developing interventions that can address existing gaps in healthcare.
Shravya Chanamolu is currently a medical student at Michigan State University College of Osteopathic Medicine with an interest in pediatric psychology. She has prior experience with mental health outreach and clinical pediatrics, and is hoping to build upon that while contributing to the THINK Lab
Alex is an undergraduate student at Wayne State University who is working towards a Neuroscience major, a French major, and a Biochemistry minor. In the future, he would like to attend medical school to become a physician and an educator. His interests include neuroscience, chemistry, music, writing, and languages.
Natalia is a junior at Wayne State University, majoring in Neuroscience and minoring in Chemistry and Biology. She
is interested in studying developmental Psychology, and the impacts of stress and drug usage on embryonic development. Additionally, she loves acquiring new skills such as painting, crocheting, and playing the piano.
Sneha is currently a second-year medical student at Wayne State University School of Medicine. She received a bachelor’s degree from UCLA in Psychobiology. She is interested in pursuing a career in pediatrics and/or psychiatry. For fun she likes to try new restaurants and outdoor activities.
Ahmad is a fourth year undergraduate student at Wayne State University pursuing a B.S. majoring in Neuroscience with a minor in Computer Science. Ahmad works as a research assistant focusing on machine learning applications in neuroimaging studies as well as participant recruitment and engagement. In his free time, he enjoys volunteer work, playing chess, programming, and spending time with his cats.
Jess is a fourth-year undergraduate student atWayne State University. She is majoring in psychology and minoring in neuroscience. She is specifically interested in neuropsychology and the relation of brain and behavior. With plans to pursue a PhD program in the future, Jess is very excited to gain experience with research at THINK lab. In her free time, she loves playing with her cat, making music, and being outdoors.
Emily is a fourth year undergraduate student at Wayne State University. She is majoring in Honors Neuroscience and minoring in Business Administration. Her research interests include pediatric and developmental neuroscience and she currently volunteers in recruitment and data collection. She is applying to medical school and hopes to work in a pediatric specialty.
The THINK lab takes PhD students through the Translational Neuroscience Program and the Pharmacology Program and will be recruiting a postdoctoral research fellow for Fall 2023. Email Dr. Marusak if interested in a PhD or postdoctoral position.
We have openings througout the year for volunteer research assistant positions. Click here to apply!
(FURRY) LAB MEMBERS
Affiliated Groups
Collaborators & community partners
Science Policy Network-Detroit
Co-founded by THINK lab members Breanna, Saurav, Shreya, and Dr. Marusak
BrainSTEM podcast
Hosted by Dr. Marusak and produced by Amanpreet and Manmeet Bhogal
Kids Kicking Cancer
International nonprofit organization
Detroit Trauma Project
PI: Tanja Jovanovic, Ph.D.
TNP2 Lab
PI: Christine Rabinak, Ph.D.
MR Research Facility
Wayne State Core Facility
The Drug Lab
Drs. Leslie Lundahl, Mark Greenwald, Eric Woodcock, and Dave Ledgerwood
Pediatric Hematology/Oncology
Division Chief: Jeffrey Taub, M.D., F.A.A.P.
Behavioral and Field Research Core
Scientific Director: Felicity Harper, Ph.D.
Adolescent Relationships in Context Lab
PI: Hannah Schacter, Ph.D.
Pediatric Epilepsy Surgery Program
Medical Director: Aimee Luat, M.D.
Wayne Pediatrics
Chief Medical Officer: Christopher Youngman, M.D.
Center for Health & Community Impact
Asst. Professor of Community Health: Jeanne Barcelona, Ph.D.
BEYOND SCIENCE
The THINK team in the lab and in the community!
Science advocacy
2023
SciPol-Detroit's second annual visit to Capitol Hill!
Summer Camp visits
2022
THINK lab member Leah Gowatch brought the brains to Crowell Recreation Center over the summer.
Capitol Hill
2022
Three THINK lab members visit Capitol Hill with Science Policy Network-Detroit to advocate for federal science funding and science-based policies!
School visits
2022
THINK lab members visited the Melvindale Medical Club to talk to high school students about the brain.
Brain Day
2022
THINK lab members volunteered at Brain Day at the Michigan Science Center.
Community events
2021
THINK lab members help pass out resources and gun locks at the 11th precinct in Detroit
Washington, D.C.
2020
Dr. Marusak advocating for federal research funding for neuroscience on behalf of the ACNP and SFN
School visits
2019
In partnership with Kids Kicking Cancer
MRI
2019
Dr. Maruask high-fiving a child who completed one of our neuroimaging studies
Celebration of Life
2019
For pediatric cancer patients and survivors
Therapeutic Techniques for the 21st Century: Pediatric Psychosocial & Palliative Care
2019
Dr. Marusak discussing the impact of stress and trauma on the brain and the benefit of martial-arts based meditative techniques
Celebration of Life
2017
For pediatric cancer patients and survivors
Contact Us!
You're awesome. Let's talk.
Phone
313.577.1993
Email
thinklab@wayne.edu
Facebook
Location
Tolan Park Medical Building 3901 Chrysler Service Drive, Suite 2B
Detroit, MI 48201
Twitter
@wsuthinklab
Research Support
If you would like to make a donation to the THINK lab or the School of Medicine, visit this link: DONATE. For THINK lab donations, hit "Other" under Designation, then write in "THINK lab".
We are thankful for research support from various funders. Our current research is supported by the National Institute of Mental Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Children's Foundation, the State of Michigan Licensing and Regulatory Affairs/Cannabis Regulatory Agency, the WSU Department of Psychiatry and Behavioral Neurosciences, and the NIH/NIEHS CURES P30 Center.
